The short version of certificate of analysis fits in a sentence. The long version — which is the one that helps — is below.
Reviewed 2026-01-14. Anything still debated is marked as such rather than presented as settled.
REV-ERB proteins help regulate daily cycles in gene expression, including genes tied to lipid and glucose metabolism. SR9009 binds these receptors and alters their activity in cell and animal experiments. Consequences observed in rodents include changes in skeletal muscle oxidative capacity, blood lipid levels, and exercise performance. The precise chain from receptor occupancy to whole-body effects is still an active area of study. Human responses cannot be assumed from rodent data.
Most published work on SR9009 consists of preclinical studies. It is widely sold as a research chemical, a category that does not imply safety, efficacy, or pharmaceutical-grade quality. Sports anti-doping organizations have listed SR9009 as a prohibited substance, and its presence in an athlete sample can lead to sanctions. Legal status differs by country; in several jurisdictions it is not approved for human consumption and may be treated as an unapproved new drug.
SR9009 is a synthetic small molecule studied as an agonist of the nuclear receptors REV-ERBα and REV-ERBβ. It is not a steroid, peptide, or natural hormone. In scientific literature, it appears under the code SR9009 and in non-scientific contexts as Stenabolic. The compound was identified through chemical screening efforts aimed at targeting circadian clock components. Its status remains investigational, and no regulatory agency has approved it as a human medicine.
Identity and purity testing for SR9009 commonly uses liquid chromatography coupled with tandem mass spectrometry. This method separates the compound from matrix components and detects it by mass-to-charge transitions, providing sensitive and specific confirmation. Nuclear magnetic resonance spectroscopy can support structural identification, while high-performance liquid chromatography with ultraviolet detection may estimate purity. Because online products labeled as SR9009 may contain other substances or no active compound at all, independent verification is important in research settings. Certificates of analysis are useful but not a substitute for in-house testing.
Laboratory samples of SR9009 are typically supplied as a white to off-white powder. The compound dissolves readily in organic solvents such as dimethyl sulfoxide and ethanol, while its solubility in water is low. Because of this solubility profile, researchers often prepare concentrated stock solutions in an organic solvent before diluting them into aqueous assay buffers. Light exposure, moisture, and repeated freeze-thaw cycles can degrade many small molecules, so handling procedures usually aim to minimize these factors. Purity is commonly checked before use.
Storage conditions for research-grade SR9009 generally involve a freezer at approximately minus twenty degrees Celsius, sometimes lower for long-term preservation. Containers should remain tightly closed and protected from light. Desiccants may be used to limit moisture uptake. Solutions are often stored in aliquots to avoid repeated warming and cooling. Stability data for the compound under various conditions are limited, so laboratories typically follow supplier recommendations and verify performance through periodic analytical checks rather than assuming indefinite stability.
| Property | Value | Notes |
|---|---|---|
| Common name | SR9009 | Also referred to as Stenabolic in non-scientific contexts. |
| Chemical class | Synthetic small molecule | Not a steroid or peptide hormone. |
| Receptor target | REV-ERBα and REV-ERBβ | Nuclear receptor agonist in preclinical studies. |
| Development status | Investigational | No approved human therapeutic indication. |
| Regulatory attention | Prohibited in sport | Listed by anti-doping authorities. |
Detection in biological samples can be complicated by rapid metabolism and low circulating concentrations. Some studies report phase I and phase II metabolites, and analytical methods may need to target those species in addition to the parent compound. Immunoassays are not broadly available, so mass spectrometry remains the main confirmatory approach. For anti-doping testing, laboratories look for SR9009 and its metabolites using validated LC-MS methods. Open questions include how long metabolites remain detectable and how different routes of administration alter detection windows.
In laboratory settings, SR9009 is typically characterized by liquid chromatography–mass spectrometry (LC-MS) or high-performance liquid chromatography with ultraviolet detection (HPLC-UV). These methods can confirm identity and estimate purity, but they require reference standards for accurate quantification. Because SR9009 is not a licensed pharmaceutical, no harmonized pharmacopeial monograph exists. Laboratories often validate in-house methods for matrices such as plasma, urine, or cell culture media. Sample preparation may involve protein precipitation or liquid-liquid extraction before analysis.
Storage recommendations for SR9009 reference material typically specify a freezer at -20 °C or lower, with protection from moisture and light. Repeated freeze-thaw cycles can degrade small molecules and introduce variability. Stock solutions in dimethyl sulfoxide are often aliquoted to avoid repeated handling. Stability studies may examine degradation under heat, humidity, and light exposure. The compound's thiophene and nitro groups can participate in reactions that alter analytical signals over time, so such changes affect quantitative results.
Quality control for research materials includes identity confirmation by nuclear magnetic resonance and purity assessment by high-performance liquid chromatography. Mass spectrometry provides molecular weight confirmation and can detect related impurities. Purchasers should request a certificate of analysis that lists lot-specific data. Online products advertised for human use often lack such documentation. Distinguishing legitimate research material from mislabeled or contaminated samples is a recurring challenge in independent testing, and independent laboratories may use orthogonal methods to verify identity.
Detection of SR9009 in biological samples usually relies on liquid chromatography coupled to tandem mass spectrometry. This approach separates the compound from matrix components and identifies it by mass transitions. Because SR9009 can undergo metabolism, laboratories often look for both parent drug and specific metabolites. Sample preparation may involve protein precipitation or solid-phase extraction. Method validation examines sensitivity, carryover, and interference from related substances, and reference standards are required for accurate calibration.
SR9009 is supplied as a solid research chemical, often in milligram quantities. Laboratories typically weigh it in a controlled environment because fine powders can disperse. Stock solutions are commonly prepared in dimethyl sulfoxide and stored in small aliquots to reduce freeze-thaw cycles. Personal protective equipment and chemical fume hoods are standard when handling unknown or potent compounds. These practices address laboratory safety rather than human use.
Identity and purity of SR9009 samples are usually checked with chromatographic and spectrometric methods. High-performance liquid chromatography can separate the compound from related impurities, while mass spectrometry provides molecular mass confirmation. Nuclear magnetic resonance spectroscopy may be used for structural verification in research settings. No single method proves biological activity, and certificates of analysis should be reviewed alongside raw data. Independent testing is often needed because online products vary widely.
== Züchterische Klassifikation == In der Zucht werden (lose entlang Combers Modell) neun verschiedene Lilien-Divisionen zur Klassifikation von Hybriden und Kultivaren unterschieden. Sieben dieser Divisionen umfassen dabei Gruppen von untereinander kreuzungsfähigen, systematisch verwandten Arten, Division 8 dient als Sammelgruppe für sonst nicht erfasste Kreuzungen und Division 9 führt Arten und ihre Kultivare auf:
Division 1: Asiatische Hybriden: Kreuzungen von Lilium amabile, Lilium bulbiferum, Lilium callosum, Lilium cernuum, Lilium concolor, Lilium dauricum, Lilium davidii, Lilium lancifolium, Lilium lankongense, Lilium leichtlinii, Lilium pumilum, Lilium wardii, Lilium wilsonii. Die Blüten sind meist klein bis mittelgroß, einfarbig oder mit kontrastierend gefärbten Blütenspitzen und Saftmalen. Flecken fehlen oder sind klar abgegrenzt. Nur schwach oder gar nicht duftend. Division 2: Martagon-Hybriden Kreuzungen von Lilium hansonii, Lilium martagon, Lilium medeoloides und tsingtauense. Frühblühend. Die Blüten sind meist klein, zahlreich und nach unten weisend; die Blütenblätter vielfach gefleckt, verdickt und zurückgebogen zur Form von Türkenbünden. Die Blüten sind duftarm oder duften unangenehm. Die Knospen sind oft behaart, die Zwiebeln oft violett oder orange-gelb. Division 3: Euro-Kaukasische Hybriden Kreuzungen von Lilium candidum, Lilium chalcedonicum, Lilium kesselringianum, Lilium monadelphum, Lilium pomponium und Lilium pyrenaicum. Die Blüten sind meist klein bis mittelgroß, häufig glocken- bis türkenbundförmig und nach unten weisend. Die Blütenfarben sind oft blässlich, Fleckungen können fehlen oder auch zahlreich vorhanden sein. Häufig duften sie, viele sind kalktolerant.
Division 4: Amerikanische Hybriden Kreuzungen von Lilium bolanderi, Lilium canadense, Lilium columbianum, Lilium grayi, Lilium humboldtii, Lilium kelleyanum, Lilium kelloggii, Lilium maritimum, Lilium michauxii, Lilium michiganense, Lilium occidentale, Lilium pardalinum, Lilium parryi, Lilium parvum, Lilium philadelphicum, Lilium pitkinense, Lilium superbum, Lilium vollmeri, Lilium washingtonianum und Lilium wigginsii. Die nur schwach duftenden Blüten sind meist klein bis mittelgroß und nach unten weisend, stark gelb bis orange-rot und deutlich gefleckt. Die Blütenblätter sind schmal, üblicherweise zurückgebogen. Division 5: Longiflorum-Lilien Kreuzungen von Lilium formosanum, Lilium longiflorum, Lilium philippinense und Lilium wallichianum. Die meist wenigen, duftenden Blüten sind meist mittelgroß bis groß und trompetenförmig und einfarbig weiß. Flecken, Papillen und Saftmale fehlen. Division 6: Trompeten- und Aurelian-Hybriden Kreuzungen von Lilium brownii, Lilium henryi, Lilium leucanthum, Lilium regale, Lilium rosthornii, Lilium sargentiae und Lilium sulphureum. Aurelian-Hybriden sind definiert als Kombination von Lilium henryi mit Trompeten-Lilien. Die Blüten sind meist mittelgroß bis groß und können jede übliche Form aufweisen. Sie sind weiß, creme, gelb bis orange oder pink, häufig mit farblich kontrastierenden sternförmigen Zeichnungen im Schlund bzw. Bänderungen auf der Außenseite. Trompeten-Hybriden sind meist duftend, ungezeichnet oder schmal gebändert am Ansatz. Die Blütenblattspitzen sind aufgebogen.
Division 7: Orientalische Hybriden Kreuzungen von Lilium auratum, Lilium japonicum, Lilium nobilissimum, Lilium rubellum und Lilium speciosum. Die oft spät blühenden, duftenden Blüten sind meist mittelgroß bis sehr groß. Die inneren Blütenblätter sind meist sehr breit und überlappen einander am Ansatz. Sie sind meist weiß bis pink bis purpurrot, gelegentlich goldgelb, oft mit weißer Grundfarbe, mit farblich kontrastierender Zeichnung im Schlund. Fleckungen fehlen oder sind zahlreich, Papillen und Nektarien sind deutlich ausgeprägt. Division 8: Andere Hybriden Kreuzungen, die von keiner der Divisionen 1 bis 7 abgedeckt sind, einschließlich aller Kreuzungen über Divisionsgrenzen hinweg. Ebenso umfasst die Division alle Hybriden von Lilium henryi mit Lilium auratum, Lilium japonicum, Lilium nobilissimum, Lilium rubellum und Lilium speciosum. Division 9: Arten und ihre Kultivare.
Sources: de.wikipedia.org
It is a synthetic compound studied as an agonist of REV-ERB nuclear receptors. It is not an approved medicine and has mainly been examined in laboratory and animal research.
No. It is a small molecule that binds nuclear receptors involved in circadian regulation. Its classification differs from anabolic steroids or peptide hormones.
Published human clinical trial data are lacking. Most safety and activity information comes from preclinical models, so effects in people remain uncertain.
Research-grade SR9009 is typically stored frozen at about minus twenty degrees Celsius, protected from light and moisture. Stock solutions are often kept in aliquots to avoid repeated freeze-thaw cycles. Specific storage conditions should follow the supplier's documentation.